CYANOCOBALAMIN (VITAMINI B12)
Mawonekedwe ndi Katundu
Chogulitsachi ndi ufa wa kristalo wofiira kapena kristalo, wopanda fungo, wopanda kukoma ndipo uli ndi mphamvu zoyambitsa chinyezi. Chimasungunuka pang'ono m'madzi kapena ethanol, sichisungunuka mu chloroform kapena ether. Chimalimbana ndi kutentha, koma sichigwira ntchito chikakumana ndi zinthu zowononga kapena zochepetsa, mchere wolemera wachitsulo, ma acid amphamvu ndi ma alkali amphamvu.
Kapangidwe ka Mankhwala
Vitamini B12 ndi gulu la equioctaphedral lomwe lili ndi ma ayoni a cobalt. Kapangidwe kake kapakati ndi mphete yathyathyathya ya corrin yopangidwa ndi ma pyrroles anayi olumikizidwa. Mamolekyu a vitamini B12 amapangidwa pafupifupi magawo atatu: mphete ya gourin yolumikizidwa ndi ma atomu anayi a N ndi ma ayoni a cobalt apakati; 5,6-dimethylbenzimidazole yolumikizidwa ku ma atomu a N-7 ndi ma ayoni a cobalt monga ma molekyulu a vitamini B 12 a ma ligands otsika. Kuphatikiza apo, DMBI imalumikizidwanso ndi aminopropanol kudzera m'magulu a phosphate, ndipo aminopropanol imalumikizidwa pamodzi ndi unyolo wa propionic acid pa pyrrole D; gulu la adenosyl kapena gulu la methyl. Imalumikizidwa ndi ma ayoni a cobalt kuti apange ligand yapamwamba ya ma molekyulu a vitamini B12.
Ntchito Yachilengedwe
Kusowa kwa Vitamini B12 kungayambitse matenda a mitsempha ya m'magazi. Zizindikiro zoyambirira za kusowa kwa vitamini B12 mwa ana ndi kusakhazikika maganizo, kufooka kwa mawu, kuchitapo kanthu pang'onopang'ono, ndipo pamapeto pake zimayambitsa kuchepa kwa magazi m'thupi. Kumalimbikitsa kukula ndi kukhwima kwa maselo ofiira a m'magazi. Methylpropandiyl coenzyme A imasinthidwa kukhala succinoyl coenzyme A ndipo imatenga nawo mbali mu tricarboxylic acid cycle, momwe succinyl coenzyme A imagwirizanirana ndi kupanga heme. Vitamini B12 imatenga nawo mbali mu kupanga deoxynucleic acid (DNA), kagayidwe ka mafuta, chakudya ndi mapuloteni, komanso kumawonjezera kupanga nucleic acids ndi mapuloteni.
